I'm currently reading Cutting for Stone for book club. I've heard several people say that it's the best book they've ever read. It's good so far!
We just finished One Day, which was good. It's being made into a movie right now.
I liked Emily Giffin's most recent book, Heart of the Matter.
If you're looking for something super light and fluffy, I read the latest in the shopaholic series: MIni-Shopaholic. Chick lit, but nice for something to read in the middle of the night while I'm nursing and can't follow anything more complicated than that.